2-{5-[3-(7-propyl-3-trifluoromethylbenzo[d]isoxazol-6-yloxy)propoxy]indol-1-yl}ethanoic acid

This compound is a synthetic small molecule with the chemical formula C24H23F3N2O5. It features a benzo[d]isoxazole core substituted with propyl and trifluoromethyl groups, linked via an ether bridge to an indole moiety, which is further connected to an ethanoic acid group[1][6]. According to structure–activity relationship (SAR) studies and computer-aided drug design literature, this molecule acts as a potent agonist of peroxisome proliferator–activated receptor gamma (PPARγ), leading to full activation of the receptor in transactivation assays[6]. PPARγ agonists are primarily investigated for their roles in metabolic diseases such as type 2 diabetes mellitus due to their effects on glucose metabolism and insulin sensitivity. There is no evidence that this compound has been approved or marketed under any brand name.

Other names

2-(5-[3-(7-propyl-3-trifluoromethylbenzo[d]isoxazol-6-yloxy)propoxy]indol-1-yl)ethanoic acid